Effects of welding parameters on the microstructure and mechanical properties of Ti/Cu/Ni joint welded by electron beam were investigated.High welding heat input increased the melting quantity of Ti60 titanium alloy and promoted the formation of Ti-Cu intermetallic compounds (IMC) such as Ti2Cu and Ti3Cu4,increasing the brittleness of the joints.Low welding heat input was not conducive to the complete melting of the copper interlayer,and the unmelted copper reduced the performance of the joints.Under the optimal welding parameters,Ti-Ni IMCs in the weld would be replaced by (Cu,Ni) solid solutions ((Cu,Ni)ss).However,Ti Cu IMC layers cannot be eliminated entirely by changing the welding parameters.The maximum tensile strength of the joints was 201 MPa.The fracture of the joints occurred at the Ti-Cu IMC layer,which was a typical brittle fracture.