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目的探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中肝再生磷酸酶(phosphatase of regenerating liver,PRL)-2、PRL-3表达情况及与微血管密度(microvessel density,MVD)的相关性,分析其表达与临床病理指标间的相关性。方法采用免疫组织化学法检测40例NSCLC患者癌组织及癌旁正常组织中PRL-2、PRL-3表达情况,并检测癌组织中MVD值,分析PRL-2、PRL-3表达水平与MVD值间相关性及其与临床病理参数间关系。结果 PRL-2、PRL-3在癌组织中阳性表达率分别为65%、70%,其表达在肿瘤分化程度、淋巴结转移情况及TNM分期上差异有统计学意义(P<0.05),在癌旁组织中均未发现阳性表达;NSCLC患者癌组织MVD值在年龄、肿瘤淋巴结转移情况及TNM分期上差异有统计学意义(P<0.05);PRL-2与PRL-3(r=0.452,P=0.008)、PRL-2与MVD(r=0.536,P=0.000)、PRL-3与MVD(r=0.452,P=0.004)呈明显正相关;PRL-2、PRL-3阳性表达者及MVD值>40者出现疾病进展例数明显高于PRL-2、PRL-3阴性者及MVD值≤40者(P<0.05)。结论 PRL-2、PRL-3异常表达时可能通过影响肿瘤新生血管的形成而促进肺癌的形成、增殖及侵袭,对临床诊疗及判定预后有一定价值。
Objective To investigate the expression of PRL-2 and PRL-3 in non-small cell lung cancer (NSCLC) and their relationship with microvessel density (MVD) The correlation between the expression and clinicopathological parameters was analyzed. Methods Immunohistochemical method was used to detect the expression of PRL-2 and PRL-3 in 40 cases of non-small cell lung cancer (NSCLC) and their adjacent normal tissues. The MVD in cancerous tissues was detected. The expression of PRL-2, PRL-3 and MVD Correlation and its relationship with clinicopathological parameters. Results The positive expression rates of PRL-2 and PRL-3 in cancer tissues were 65% and 70%, respectively. The expression of PRL-2 and PRL-3 was significantly different in the degree of tumor differentiation, lymph node metastasis and TNM staging (P <0.05) There was no significant difference in the expression of PRL-2 and PRL-3 (r = 0.452, P <0.05). The positive expression of MVD in cancer tissue of NSCLC patients was significantly different from that in age, tumor lymph node metastasis and TNM stage PRL-2 and MVD (r = 0.536, P = 0.000), PRL-3 and MVD (r = 0.452, P = 0.004) The number of patients with a disease score> 40 was significantly higher than those with PRL-2, PRL-3, and MVD ≤ 40 (P <0.05). Conclusions The abnormal expression of PRL-2 and PRL-3 may promote the formation, proliferation and invasion of lung cancer by affecting the formation of neovascularization, which is of value to clinical diagnosis and prognosis.