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将47例出血热患者分为前列腺素 E_1(PGE_1)治疗组(16例)和对照组(31例)。PGE_1用法为200μg/天×3天,静脉滴注;对照组只进行对症和支持治疗。结果发现两组在越期率、少尿期和多尿期持续时间,以及病死率等均无显著差异,提示用本文所用的 PGE_1剂量和疗程无明显疗效。两组病人各期 TXB_2水平和正常值无显著差异;而6-酮-PGE_(1α)水平两组发热期均高于正常值,对照组恢复期水平也有增高。
47 patients with hemorrhagic fever were divided into prostaglandin E_1 (PGE_1) treatment group (16 cases) and control group (31 cases). PGE 1 usage 200μg / day × 3 days, intravenous infusion; control group only symptomatic and supportive treatment. The results showed no significant difference in over-the-lead rate, duration of oliguria and polyuria, as well as mortality, suggesting no significant effect of the dose and course of PGE 1 used in this study. There was no significant difference between the two groups in the levels of TXB_2 and the normal levels. The levels of 6-keto-PGE_ (1α) fever in both groups were higher than the normal values and the convalescent levels in the control group also increased.