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鼻咽癌具有显著的地理差异和种族差异．该病在中国南方和东南亚地区高发．虽然家族聚集现象已被多次报道，且遗传易感性被认为是鼻咽癌发病中最重要的危险因素之一，但是它的遗传模式目前还不清楚．为了研究广东家族性鼻咽癌的遗传模式，作者采用了ＳＡＧＥ软件的ＲＥＧＤ程序进行了复合分离分析．文章对１３６个高危家系进行了研究；这些家系中均具有两个或以上鼻咽癌患者．先征者来自于在中山医科大学肿瘤中心诊治的患者．结果提示该研究群体的遗传模式复合常染色体显性或共显性遗传模式，常染色体显性遗传模式的拟合最佳．该结果增加了主基因存在的证据，为家族性鼻咽癌的连锁分析提供了重要的支持．
Nasopharyngeal carcinoma has significant geographical and ethnic differences. The disease is high in southern China and Southeast Asia. Although familial aggregation has been reported many times and genetic susceptibility is considered as one of the most important risk factors in the pathogenesis of NPC, its genetic model is not yet clear. In order to study the genetic model of familial NPC in Guangdong, the authors used the REGD program of SAGE software to perform composite separation and analysis. The article studied 136 high-risk pedigrees; these families have two or more NPC patients. The first one came from the patients who were diagnosed and treated in the tumor center of Zhongshan Medical University. The results suggest that the genetic model of the study group compound autosomal dominant or co-dominant genetic model, autosomal dominant genetic model fitting the best. This result adds to the evidence of the presence of major genes and provides important support for the linkage analysis of familial NPC.