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目的用４种大黄蒽醌化合物抑制幽门螺杆菌（Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉ，Ｈｐ）的实验研究方法用梯度酸碱提取法，将大黄中的４种蒽醌类化合物提取，然后用试管稀释法和纸片扩散法，分别观察它们对Ｈｐ的抑菌效果．结果４种大黄蒽醌，它们稀释度及抑制Ｈｐ环分别为∶大黄素（ｅｍｏｄｉｎ）为１∶２５２（３０ｍｍ，强）、大黄酸（ｒｈｅｉｎ）为１∶１６８（２８ｍｍ，强）、大黄酚（ｃｈｒｙｓｏｐｈａｎｏｌ）为１∶１２８（２４ｍｍ，强）、芦荟大黄素（ａｌｏｅｅｍｏｄｉｎ）为１∶１１８（２３ｍｍ，强），对照品大黄提取物（Ｒｈｅｕｍｏｆｉｃｉｎａｌｅｅｘｔｒａｃｔｓ）仅为１∶５８（１５ｍｍ，中）．结论４种大黄蒽醌化合物均具有较强的抑制Ｈｐ的生长作用．
OBJECTIVE To study the inhibitory effect of four rhubarb anthraquinone compounds against helicobacter pylori (Helicobacter pylori, Hp) by using gradient acid-base extraction method. Four kinds of anthraquinones were isolated from rhubarb and then diluted with test tube and diffusion method , Respectively, to observe their inhibitory effect on Hp. Results Four rhubarb anthraquinones, their dilution and inhibition of Hp ring were: 1: 252 (30 mm, strong) for emodin, 1: 168 for rhein (28 mm, Chrysophanol was 1:128 (24mm, strong), aloe-emodin was 1:118 (23mm, strong) and Rheumoficinaleextracts was only 1:58 (15mm, middle). Conclusions All four rhubarb anthraquinones have a strong inhibitory effect on the growth of Hp.