抗生素静脉给药,一般采用重力液流间断滴注的方法。有些研究证明,重力液流滴注时因液滴速度和液滴的大小使输液速度明显地改变了。作者曾用妥布拉霉素比较,重力液流法比膜控释装置峰浓度的到达为迟,庆大霉素用液流输注,药物峰浓度低于预测浓度。该研究用健康志愿者验证膜控释装置的可行性。控释膜输液装置由两个室组成,其间用0.2μm 的微孔膜隔开。该膜由 FDA 提供的用于静脉注射级医用塑料制成,加药物为注 Antibiotic intravenous administration, the general gravity flow intermittent infusion method. Some studies have shown that the infusion rate is significantly changed by the droplet velocity and the size of the droplet when gravity flow is instilled. The authors have used tobramycin comparison, gravity flow method than the membrane controlled release device peak concentration arrived late, gentamicin infusion by flow, the drug peak concentration is lower than the predicted concentration. The study used healthy volunteers to verify the feasibility of membrane controlled release devices. Controlled release membrane infusion device consists of two chambers, with a 0.2μm microporous membrane. The membrane is made of FDA-supplied medical grade plastic for intravenous injection, with medication as a note