论文部分内容阅读
目的：探讨用化疗药膀胱内灌注预防浅表性膀胱癌术后复发。方法：将患者随机分为噻替哌组（３５例）、丝裂霉素Ｃ组（３２例），分别用化疗药物行膀胱内灌注，观察１～３年复发率，并与对照组（未灌药２２例）作比较。结果：３年复发率噻替哌组４８．６％，丝裂霉素组４０．６％，对照组７７．３％；治疗组与对照组差异有显著性（Ｐ＜０．０５）。各组复发中位时间分别为２２．７月、２９．２月、１０．８月，治疗组与对照组差异有显著性（Ｐ＜０．０１）。结论：噻替哌、丝裂霉素Ｃ膀胱内灌注可预防浅表性膀胱癌术后复发或推迟其复发时间。
Objective: To investigate the use of chemotherapeutic agents for intravesical instillation to prevent postoperative recurrence of superficial bladder cancer. METHODS: Patients were randomly divided into thiotepa group (35 cases) and mitomycin C group (32 cases). Intravesical instillation was performed with chemotherapeutic agents and the recurrence rate was observed for 1 to 3 years. Pouring medicine in 22 cases) for comparison. Results: The 3-year recurrence rate was 48.6% in the thiotepa group, 40.6% in the mitomycin group, and 77.3% in the control group; there was a significant difference between the treatment group and the control group (P<0.05). The median time to recurrence in each group was 22.7 months, 29.2 months, and 10.8 months, respectively, and there was a significant difference between the treatment group and the control group (P<0.01). CONCLUSION: Intravesical instillation of thiotepa and mitomycin C can prevent postoperative recurrence of superficial bladder cancer or postpone its recurrence.