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[目的]探讨超声造影时间—强度曲线(TIC)在评估宫颈癌新辅助化疗疗效中的价值。[方法 ]对40例行新辅助化疗宫颈癌患者于化疗前和化疗2个疗程后采用超声造影和磁共振成像(magnetic resonance imaging,MRI)检查测量肿物最大径,以病理结果为金标准比较两种影像学方法测量的精确性。观察造影剂灌注情况,应用时间—强度曲线分析病变造影剂的到达时间(AT)、达峰时间(TTP)以及峰值强度(PI),比较化疗前后各参数的变化。[结果]1超声造影与MRI测量精确性未见明显差异(P>0.05)。2化疗有效组32例患者肿物明显缩小,TIC显示TTP较化疗前明显延长(P<0.05),PI下降(P<0.05);化疗无效组8例患者肿物缩小不明显,TTP与化疗前比较未见明显变化(P>0.05),PI有所增高,但无统计学差异(P>0.05)。两组患者的AT均较化疗前延长,但无统计学差异(P>0.05)。[结论]超声造影可作为肿物测量方法之一,时间—强度曲线参数可客观反映化疗前后宫颈肿物的血流灌注变化情况,有助于新辅助化疗效评估。
[Objective] To investigate the value of contrast-enhanced ultrasound (TIC) in evaluating the efficacy of neoadjuvant chemotherapy for cervical cancer. [Method] Forty patients underwent neoadjuvant chemotherapy for cervical cancer before radiotherapy and two cycles of chemotherapy after radiotherapy. The maximum diameter of tumor was measured by contrast-enhanced ultrasound and magnetic resonance imaging (MRI). The pathological results were compared with the gold standard Accuracy of two imaging methods. The perfusion of contrast agent was observed. The time of arrival (AT), peak time (TTP) and peak intensity (PI) of contrast agent were analyzed by time-intensity curve. The changes of parameters before and after chemotherapy were compared. [Results] 1 There was no significant difference between the accuracy of ultrasound and MRI (P> 0.05). TIC showed that TTP was significantly longer than before chemotherapy (P <0.05), PI was decreased (P <0.05); 8 patients with chemotherapy-ineffective group did not shrink significantly, TTP was significantly lower than that before chemotherapy Compared with no significant change (P> 0.05), PI increased, but no significant difference (P> 0.05). AT in both groups was longer than that before chemotherapy, but there was no significant difference (P> 0.05). [Conclusion] Contrast-enhanced ultrasound can be used as one of the measurement methods of tumor. Time-intensity curve parameters can objectively reflect the changes of blood perfusion of cervical masses before and after chemotherapy, which is helpful to assess the effect of neo-adjuvant chemotherapy.