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作者用安坦治疗22例不同病因所致的肌张力异常(dystonia),并随访了6年.开始剂量为6mg/天,逐渐增到症状改善或出现了副作用.1例最大剂量达到30mg/天.11例儿童,年令8～15岁,9例为全身性的,1例为节段性的,1例为一侧性的.在8例遗传性或特发性肌张力异常(扭转性肌张力异常或变性型肌张力异常)的患儿中有6例获得中等～明显地改善.其中有1例患儿延迟到剂量达30mg/天才开始恢复.在3例继发性肌张力异常的患儿中有2例获明显改善和完全缓解.仅3例无效.其中1例剂量20mg/天而无反应,而另外2例开始治疗后症状加重,停止了治疗.
The authors treated 22 patients with dystonia of various etiologies and were followed up for 6 years with a dose of 6 mg / day starting with amphetamines and gradually increasing to symptoms or side effects.1 The maximum dose reached 30 mg / day .11 cases of children, aged 8 to 15 years old, 9 cases of systemic, 1 case of segmental, 1 case of one-sided in 8 cases of genetic or idiopathic dystonia (torsion 6 cases of moderate to significant improvement in children with abnormal muscle tone or anamorphic dystonia.One of the children was delayed until the dose reached 30mg / day to begin recovery.In 3 cases of secondary dystonia Two of the children were significantly improved and completely relieved, only three were ineffective, one of whom had a dose of 20 mg / day without response and the other two who started to have symptoms worsened and stopped treatment.