本文报道了近年来国内、外新的及常用的39种抗菌药物对436株细菌的体外抗菌活性研究。这些细菌均系临床分离所得,试验方法为试管对倍稀释法。结果表明新的抗菌药物特别是第三代头孢菌素、Imipenem、哌拉西林、阿洛西林、丁胺卡那霉素、氟哌酸和氟嗪酸等的抗菌活性强、抗菌谱广。这些新药对其敏感菌株所致感染是非常有效的;对金葡球菌所致感染仍以耐青霉素酶的青霉素,如苯唑青霉素和邻氯青霉素等为最有效的药物。 In this paper, we report the in vitro antibacterial activities of 436 antibacterials against 39 kinds of antibacterials at home, abroad, and abroad. These bacteria are clinically isolated from the test method for the test tube doubling dilution method. The results showed that the new antibacterial drugs, especially the third-generation cephalosporins, Imipenem, piperacillin, azlocillin, amikacin, norfloxacin and fluorozinc acid antibacterial activity, broad antibacterial spectrum. These new drugs are very effective against infections caused by their susceptible strains. Penicillin-resistant penicillins, such as oxacillin and ciclopirox, are still the most effective drugs against Staphylococcus aureus.