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自1988年以来,在波恩血友病中心的46例HAV易感的血友病患者(平均年龄21岁)中有13例(平均年龄10岁)发生了HAV感染(1988年4例,1990年3例,1991年4例,1992年2例)。经追踪调查,这些HAV感染者均与使用凝血因子Ⅷ制剂有关。而23例
Thirteen (mean age 10 years) of 46 HAV-susceptible hemophilia patients (mean age 21 years) at the Bonn Center for Hemophilia at Bonn developed HAV infection since 1988 (4 in 1988 and 1990 3 cases, 4 cases in 1991, 2 cases in 1992). After follow-up investigation, these HAV infections were associated with the use of factor VIII agents. While 23 cases