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目的:探讨系统性红斑狼疮(SLE)患者的抗磷脂抗体(APA)水平及凝血指标纤维蛋白原(FIB)、D-二聚体(D-D)表达与易栓状态的相关性。方法:92例SLE患者和30例正常对照者取静脉全血,应用ELISA法检测APA的表达水平,应用磁珠法检测FIB、D-D的表达水平。结果:SLE患者初治、活动期和稳定期APA、FIB、D-D的表达均显著高于对照组(P<0.05);稳定期上述指标均低于初治期和活动期(P<0.05);APA水平与凝血指标FIB、D-D表达呈同步增高趋势。结论:SLE患者伴有凝血功能紊乱,APA水平的异常表达为导致SLE易栓症的重要因素之一。
Objective: To investigate the relationship between anti-phospholipid antibody (APA) levels and the expression of fibrinogen (FIB) and D-dimer (D-D) in patients with systemic lupus erythematosus (SLE) Methods: 92 cases of SLE patients and 30 normal controls were taken venous blood. The expression of APA was detected by ELISA. The expression of FIB and D-D was detected by magnetic beads method. Results: The expression of APA, FIB and DD in initial stage, active stage and stable stage of SLE patients were significantly higher than those in control group (P <0.05). The above indexes in stable stage were lower than those in initial stage and active stage (P <0.05). APA level and coagulation index FIB, DD expression showed a synchronous increase trend. Conclusion: The coagulation disorder is associated with SLE. The abnormal expression of APA is one of the important factors leading to SLE.