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目的 :探讨CA1 9-9测定在消化道肿瘤诊断中的意义。方法 :用放免疫法 (RIA)测定的 1 5 9例消化道恶性肿瘤患者血清中的浓度 ,并以 1 65例良性消化系统疾病作对照。结果 :肝癌、胃癌、胰腺癌和肠癌患者血清中CA1 9-9水平明显高于其良性病变 (P <0 .0 1 ) ,食管癌也高于其良性病变 (P <0 .0 5 )。其阳性率以胰腺癌最高 74.0 7% ,其次分别是肝癌 (70 .3 7% )、胃癌(63 .63 % )、肠癌 (5 4.5 5 % )和食管癌 (40 .1 9% )。结论 :CA1 9-9对胰腺癌的诊断价值最大 ,对肝癌、胃癌、肠癌和食管癌都有一定的诊断意义 ,可作为消化道肿瘤诊断的参考指标之一。
Objective: To investigate the significance of CA1 9-9 in the diagnosis of gastrointestinal tumors. Methods: Serum levels of 159 patients with gastrointestinal malignancies measured by radioimmunoassay (RIA) were compared with 165 healthy patients with benign digestive diseases. Results: Serum levels of CA1 9-9 in patients with liver cancer, gastric cancer, pancreatic cancer and colorectal cancer were significantly higher than those in benign lesions (P <0.01) and esophageal cancer (P <0.05) . The positive rate of pancreatic cancer was 74.0 7%, followed by liver cancer (70.37%), gastric cancer (63.63%), intestinal cancer (4.55%) and esophageal cancer (40.19%). Conclusion: CA1 9-9 has the highest diagnostic value for pancreatic cancer, and has certain diagnostic value for liver cancer, gastric cancer, intestinal cancer and esophageal cancer, and can be used as a reference index for the diagnosis of gastrointestinal cancer.