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目的探讨传统治疗与多靶点治疗难治性狼疮性肾炎的临床效果对比情况。方法选取2012年6月~2013年6月来我院接受治疗的50例难治性狼疮性肾炎患者,随机将其分为观察组和对照组各25例,给予对照组患者采用传统方式治疗,给予观察组患者采用多靶点方式治疗,比较两组患者的治疗效果。结果观察组患者完全缓解的有16例,部分缓解的有7例,总有效率达到92%,对照组患者完全缓解的有5例,部分缓解的有10例,总有效率为60%,观察组的治疗效果明显要好于对照组,P<0.05。在药物治疗所产生的不良反应方面的比较上,观察组有1例出现骨髓抑制,2例血压升高,1例感染,对照组患者有6例肝酶升高,7例骨髓抑制,4例血压升高,12例感染,观察组患者不良反应明显要少于对照组患者,P<0.05。结论采用环磷酰胺联合他克莫司以及泼尼松等多靶点治疗难治性狼疮性肾炎具有良好的临床效果,药物的联用能有效降低医疗成本,不良反应也比较少,值得在临床上广泛推广和应用。
Objective To investigate the clinical effects of traditional and multi-target therapy on refractory lupus nephritis. Methods Fifty patients with refractory lupus nephritis treated in our hospital from June 2012 to June 2013 were randomly divided into observation group (25 cases) and control group (25 cases). Patients in control group were treated by traditional method, Patients in the observation group were treated with multi-target method, and the treatment effect was compared between the two groups. Results In the observation group, 16 cases were completely relieved, 7 cases partially relieved, the total effective rate was 92%, 5 cases completely relieved in the control group, 10 cases partially relieved, and the total effective rate was 60% The treatment group was significantly better than the control group, P <0.05. There were 1 case of myelosuppression, 2 cases of hypertension and 1 case of infection in the observation group. There were 6 cases of elevated liver enzymes in the control group, 7 cases of myelosuppression and 4 cases of bone marrow suppression Blood pressure, 12 cases of infection, adverse reactions in the observation group was significantly less than the control group, P <0.05. Conclusions The combination of cyclophosphamide with tacrolimus and prednisone has a good clinical effect in the treatment of refractory lupus nephritis. The combination of drugs can effectively reduce the cost of medical treatment, with relatively few adverse reactions, which is worthy of clinical application Extensive promotion and application.