骨髓造血微环境主要由基质细胞和细胞外基质（ＥＣＭ）构成，基质细胞包括多种细胞成分，如成纤维细胞、内皮细胞、脂肪细胞、巨噬细胞等，可分泌多种造血调控因子，调节造血干、祖细胞的增殖分化和自我更新［１］。基质细胞可以合成ＩＬ６参与造血调控，已为许多学者证实［ Bone marrow hematopoietic microenvironment is mainly composed of stromal cells and extracellular matrix (ECM), stromal cells including a variety of cellular components such as fibroblasts, endothelial cells, adipocytes, macrophages, etc., can secrete a variety of hematopoietic regulatory factors, regulate Hematopoietic stem and progenitor cells proliferation and differentiation and self-renewal [1]. Stromal cells can be synthesized IL 6 involved in hematopoietic regulation, has been confirmed by many scholars [