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【目的】了解中国育龄女性癫痫患者发生生殖内分泌紊乱的相关危险因素,为临床决策提供依据。【方法】收集符合研究标准的102例女性癫痫患者的临床资料,将癫痫起病年龄、发作类型、发作频率、癫痫病程、抗癫痫药物(AED)种类、开始服用AED的年龄、用药持续时间7个因素分组,分析各因素与月经稀发/闭经、多囊卵巢(PCO)、高雄激素血症(HA)、多囊卵巢综合征(PCOS)的关系。【结果】癫痫起病年龄≤14岁者较起病年龄>14岁者HA高发并具统计学意义;服用丙戊酸钠的患者月经稀发/闭经、PCO、HA、PCOS发生率分别达40.63%、50.00%、15.65%和34.38%,显著高于未用药组及其他用药组。Logistics回归分析结果表明:服用丙戊酸钠是发生生殖内分泌紊乱及PCOS的危险因素。癫痫起病年龄≤14岁是HA的危险因素。【结论】服用丙戊酸钠是中国育龄女性癫痫患者发生生殖内分泌紊乱乃至PCOS的危险因素,癫痫起病年龄≤14岁是HA的危险因素。
【Objective】 To understand the related risk factors of reproductive and endocrine disorders in Chinese women of childbearing age and provide the basis for clinical decision-making. 【Methods】 The clinical data of 102 female patients with epilepsy who meet the research criteria were collected. The age of onset of epilepsy, the type of seizure, the frequency of seizure, the course of epilepsy, the type of AED, the age of starting AED, the duration of medication 7 The factors were divided into groups to analyze the relationship between various factors and oligomenorrhea / menopause, polycystic ovary (PCO), hyperandrogenism (HA) and polycystic ovary syndrome (PCOS). 【Results】 The incidence of epilepsy was less than 14 years of age than the onset of age> 14 years old HA high incidence and statistical significance; taking sodium valproate in patients with menstruation rare / amenorrhea, PCO, HA, PCOS incidence rates were 40.63 %, 50.00%, 15.65% and 34.38%, respectively, which were significantly higher than those of the untreated and other medication groups. Logistics regression analysis showed that taking sodium valproate was a risk factor for reproductive endocrine disorders and PCOS. The onset of epilepsy ≤ 14 years old is a risk factor for HA. 【Conclusion】 Sodium valproate is a risk factor for reproductive and endocrine disorders and even PCOS in Chinese women of childbearing age. The onset of epilepsy is less than 14 years old and is a risk factor for HA.