目的探讨重型妊娠期肝内胆汁淤积症合并乙肝病毒感染对围生儿的影响方法用回顾性方法分析2012年7月2014年8月在我院住院治疗的196例重型妊娠期肝内胆汁淤积症(ICP)孕妇,其中有乙肝病毒感染(HBV)的34例为HBV+ICP组,无HBV感染的162例为单纯重型ICP组,比较两组ICP的病情、妊娠结局.结果HBV+ICP组的直接胆红素、总胆红素、ALT、AST、胆汁酸明显升高,但两组中仅直接胆红素的差异有统计学意义(P〈0.05),两组的羊水Ⅲ°污染、胎儿窘迫、新生儿窒息率比较,差异皆有统计学意义(P〈0.05),两组的剖宫产率、产后出血、新生儿体重比较差异无统计学意义(P〉0.05);结论重型ICP合并HBV感染可加重围生儿的不良妊娠结局. “,”Objective Discussion the influence of severe disease of intrahepatic cholestasis during pregnancy (ICP)with hepatitis B virus (HBV)infection on perinatal. Methods Reviewed 196 cases of severe ICP pregnant women m July 2012 to August 2014 in our study,which 34 cases with hepatitis B infection was the HBV+ICP group, comparied with 162 cases as the isolated ICP group,the impact of hepatitis B Virus infection on the course,pregnancy outcome of ICP were studied.Results the levels of direct bilimbin, total bilirubin,ALT,AST and bile acid in the HBV+ICP group were significantly higher, but only the difference of the direct bilirubin was statistically significant (P〈0.05);The difference of amniotic fluid Ⅲ° pollution fetal distress neonatal asphyxia was statistically significant (P〈0.05),while the difference of the cesarean section rate,postpartum hemorrhage and neonatal weight was no statistically significant (P〉0.05).Conclusion Severe 1CP with FtBV infection may increase the adverse pregnancy outcomes on perinatal.