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目的:探讨AnnexinⅡ和Annexin IV在大肠癌中的表达及其临床意义。方法:用免疫组化SP法分别检测AnnexinⅡ和Annexin IV在60例大肠癌组织中的表达。结果:(1)AnnexinⅡ和Annexin IV在大肠癌组织中的阳性表达率分别为65%(39/60)和60%(36/60);(2)AnnexinⅡ和Annexin IV阳性和阴性病例的平均生存期、五年生存率和中位生存期比较,差异具有显著性(P<0.05);(3)大肠癌组织中AnnexinⅡ和Annexin IV的表达一致率为68.33%(41/60),存在显著相关性(P<0.01);(4)大肠癌不同临床时期(Ⅱ、Ⅲ和Ⅳ)AnnexinⅡ和Annexin IV阳性表达比较,差异具有显著性(P<0.01)。结论:AnnexinⅡ和Annexin IV与大肠癌的临床分期和预后有关。
Objective: To investigate the expression of Annexin Ⅱ and Annexin IV in colorectal carcinoma and its clinical significance. Methods: The expression of Annexin Ⅱ and Annexin IV in 60 cases of colorectal carcinoma were detected by immunohistochemical SP method. Results: (1) The positive rates of Annexin Ⅱ and Annexin IV in colorectal cancer tissues were 65% (39/60) and 60% (36/60) respectively. (2) The average survival rate of Annexin Ⅱ and Annexin IV positive and negative cases (3) The consistent rate of AnnexinⅡand Annexin IV expression in colorectal cancer was 68.33% (41/60), which was significantly correlated with the survival rate, median survival time and median survival time (P <0.05) (P <0.01). (4) The positive expression rates of Annexin Ⅱ and Annexin IV in different clinical stages (Ⅱ, Ⅲ and Ⅳ) of colorectal cancer were significantly different (P <0.01). Conclusion: Annexin Ⅱ and Annexin IV are related to the clinical stage and prognosis of colorectal cancer.