大环内酯类抗生素是一类极其重要的抗生素,自1952年McQuire发现第一个大环内酯类抗生素——红霉素以来,由于其具有独特的抗菌效果,对革兰氏阳性菌及耐药金葡菌,多种厌氧菌有高效外,并对一些新的致病菌,如军团菌、弯曲杆菌、枝原体、衣原体感染及性病等也有很好治疗作用,因此一直被人们所重视。继红霉素后国内市场尚有麦迪霉素、麦白霉素、螺旋霉素、吉他霉素、交沙霉素及它们的衍生物,如乙酰螺旋霉素、乙酰麦迪霉素等 Macrolide antibiotics are a class of extremely important antibiotics. Since McQuire discovered the first macrolide antibiotic, erythromycin, in 1952, its antibacterial effect has been proved to be of great value to Gram-positive bacteria and Resistant Staphylococcus aureus, a variety of anaerobic bacteria with high efficiency, and for some new pathogens, such as Legionella, Campylobacter, Mycoplasma, Chlamydia infection and sexually transmitted diseases also have a good therapeutic effect, it has been people Attention. Following the domestic market of erythromycin, there are still midecamycin, melemycin, spiramycin, gentamicin, josamycin and their derivatives, such as acetylspiramycin, acetyl midecamycin, etc.