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目的 :观察不同剂量的川芎嗪加入到 4 2 5%透析液中对腹膜超滤功能的影响。方法 :4 0只SD大鼠随机分为 4组 ,除对照组外 ,其余 3组每日分别腹腔注射 2 5ml 4 .2 5%透析液 (HGC) ,HGC加低剂量( 4 0mg/L)川芎嗪 (HGL)和HGC加高剂量 ( 160mg/L)川芎嗪 (HGH)。至第 4 5天结束时 ,以131I标记的白蛋白溶于 2 5ml 4 2 5%透析液注入腹腔 ,进行腹膜功能试验。结果 :与对照组比较 ,各透析组 4h排液量显著降低 ,而HGL组排液量显著高于HGC组和HGH组。各透析组腹透液重吸收和直接淋巴吸收均显著高于对照组 ,各透析组之间比较则差异无显著性。HGL组透析液与血浆尿素浓度之比 (D/Purea)与HGC组比较无显著性差异 ,但透出液中葡萄糖浓度与未使用过的 4 2 5%透析液中葡萄糖浓度之比 (D/D0 )及尿素清除率(Curea)显著高于HGC组和HGH组 ;HGH组D/Purea显著增加。结论 :低剂量川芎嗪加入到腹透液中可减少高渗透析液引起的腹膜功能损伤 ,增加超滤及透析效能 ,高剂量川芎嗪则可引起腹膜通透性增高。
Objective : To observe the effect of different doses of tetramethylpyrazine added to 42 5% dialysate on peritoneal ultrafiltration. METHODS: Forty Sprague-Dawley rats were randomly divided into 4 groups. Except for the control group, the other three groups were intraperitoneally injected with 25 ml of 4.2% 5% dialysate (HGC) daily, and HGC plus low dose (40 mg/L). Ligustrazine (HGL) and HGC plus high dose (160mg/L) Ligustrazine (HGH). At the end of the 45th day, 131I-labeled albumin was dissolved in 25 ml of 45% 5% dialysate and injected into the abdominal cavity for peritoneal function tests. RESULTS: Compared with the control group, the dialysis group’s 4h drainage volume was significantly reduced, while the HGL group’s drainage volume was significantly higher than the HGC group and the HGH group. Peritoneal fluid reabsorption and direct lymphatic absorption were significantly higher in the dialyzed groups than in the control group. There was no significant difference between the dialyzed groups. The ratio of dialysate to plasma urea concentration in the HGL group (D/Purea) was not significantly different from that in the HGC group, but the ratio of glucose concentration in the dialysate to the glucose concentration in the unused 4 25% dialysate (D/ D0) and urea clearance rate (Curea) were significantly higher than those of HGC group and HGH group; D/Purea of HGH group was significantly increased. Conclusion : Low-dose tetramethylpyrazine can reduce peritoneal dysfunction caused by hyperosmolar fluid and increase ultrafiltration and dialysis efficacy when added to dialysate. High-dose ligustrazine can cause increased peritoneal permeability.