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目的:观察早期应用纳洛酮治疗新生儿缺氧缺血性脑病的疗效。方法:将64例患儿随机分为两组。对照组(30例)用综合疗法。治疗组(34例)在综合疗法的基础上加用纳洛酮,0.2mg注入10％葡萄糖注射液20ml中,2小时内滴完,间隔1小时再重复1次。连用2～3天。结果:治疗组与对照组总有效率分别为94.1％和66.7％,新生儿行为神经评分(NBNA)平均恢复时间分别为8.06和9.74天,平均住院天数分别为10.4±2.1天和14.4±1.02天,两组相比差异显著(P<0.01)。结论:对缺氧缺血性脑病患儿早期应用纳络酮治疗可提高疗效,缩短疗程,减少后遗症。
Objective: To observe the curative effect of early application of naloxone on neonatal hypoxic-ischemic encephalopathy. Methods: 64 children were randomly divided into two groups. Control group (30 cases) with combination therapy. The treatment group (n = 34) was treated with naloxone on the basis of the combination therapy, and 0.2 mg of 10 mg glucose was injected into 20 ml of dextrose injection. The treatment group was dripped within 2 hours and then repeated 1 hour at intervals of 1 hour. Used together for 2 to 3 days. Results: The total effective rates of the treatment group and the control group were 94.1% and 66.7% respectively. The mean time to recovery of neonatal behavioral neurological score (NBNA) was 8.06 and 9.74 days respectively, and the average hospitalization days were 10.4 ± 2.1 days and 14.4 ± 1.02 days respectively , There was significant difference between the two groups (P <0.01). Conclusion: The early application of naloxone in children with hypoxic-ischemic encephalopathy can improve the curative effect, shorten the course of treatment and reduce the sequelae.