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麻醉开胸大鼠结扎冠脉左室支３０ｍｉｎ后再灌注６０ｍｉｎ造成大鼠心肌缺血再灌注损伤，在再灌注的同时恒速ｉｖ黄芪（８３０ｍｇ／ｋｇ）对上述心肌损伤有明显的防护作用，表现为明显降低再灌注性心律失常室速（ＶＴ）及室颤（ＶＦ）的发生率，延迟其出现时间并缩短其持续时间，促进缺血型ＳＴ段的恢复。减少心肌细胞内Ｃａ２＋的蓄积及细胞内磷酸肌酸激酶同功酶（ＣＫ－ＭＢ）的漏出。明显降低心肌组织中ＭＤＡ含量并显著提高ＳＯＤ和ＧＳＨ－Ｐｘ的活性。结果提示黄芪防护心肌缺血再灌注损伤的作用与其提高心肌的抗氧化能力、清除氧自由基、减轻细胞膜脂质过氧化状态和维持细胞膜的完整性相关。
Anesthetize rats with thoracotomy left ligation of the left ventricular branch 30min and then reperfusion for 60min caused myocardial ischemia-reperfusion injury in the same time reperfusion, iv iv Astragalus (830mg / kg) on the myocardial injury was significantly protective effect, The results showed that the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF) was significantly decreased in reperfusion arrhythmia, delayed its appearance and shortened its duration, and promoted the recovery of ischemic ST segment. Reduce the intracellular Ca2 + accumulation and intracellular phosphokinase kinase (CK-MB) leakage. Significantly reduce myocardial MDA content and significantly increase the activity of SOD and GSH-Px. The results suggest that the function of Astragalus membranaceus to protect myocardium against ischemia-reperfusion injury is related to its ability of enhancing the anti-oxidative capacity, scavenging oxygen free radicals, reducing lipid peroxidation and maintaining cell membrane integrity.