系统性硬皮病的确切病因仍未明确,目前多倾向于是血管异常、免疫学异常、胶原异常而引起的肺、肾、皮肤等器官的损伤。针对血管和免疫学异常的最佳干预和治疗时间应在疾病的早期,而大多数患者在被确诊时往往已经患病多年,因而针对胶原异常导致组织纤维化发生机制和治疗的研究仍将受到广大医学工作者的重视。本文就系统性硬皮病组织纤维化的研究进展作一综述。 The exact etiology of systemic scleroderma is still not clear, at present tend to be vascular abnormalities, immunological abnormalities, collagen abnormalities caused by lung, kidney, skin and other organ damage. The best intervention and treatment time for vascular and immunological abnormalities should be in the early stages of the disease, and most patients are often already afflicted for many years when diagnosed, and therefore research into the mechanisms and treatments for tissue fibrosis that result from aberrant collagen remains The majority of medical workers attention. This article reviews the research progress of systemic scleroderma tissue fibrosis.