钾离子内向整流通道Kir6 .2与胰岛素释放密切相关 ,其与磺脲类受体 (SUR) 2共同构成胰岛B细胞膜上ATP敏感的钾通道。已发现的Kir6 .2的突变类型有 4个错义突变E10R ,E2 3K ,L2 70V ,I337V和两个安静突变A190A ,L2 6 7L。与 2型糖尿病相关研究表明 ,在法国高加索族白种人人群中 ,位点E2 3K的多态性意义重大 ,而 2 3,337位纯合子突变 ,2 70位为杂合子型导致健康正常人的胰岛素敏感性改变。 Kir6.2, an inward rectifier channel of potassium, is closely related to insulin release, which together with sulfonylurea receptor (SUR) 2 forms ATP-sensitive potassium channels on islet B cell membrane. Mutations of Kir6.2 that have been found have four missense mutations E10R, E2 3K, L2 70V, I337V and two silent mutations A190A, L2 6 7L. Studies with type 2 diabetes have shown that polymorphisms in the E2 3K locus are significant in Caucasus Caucasian populations in France, with 2,337 homozygous mutations and 270 with heterozygotes leading to insulin in healthy, normal individuals Sensitivity changes.