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近几年开始应用从生皮中提取的注射用无毒性胶原治疗压力性尿找禁.目前所用胶原是一种戊(?)醛交联物质(GAX 胶原),注入这种胶原以替代病人的内源性胶原.作者通过测定病人漏尿量和分析病人主观反应,评价尿道周围注射胶原治疗压力性尿失禁的疗效.病人共12例,经尿流动力学证实为Ⅰ型或Ⅲ型压力性尿失禁,年龄46～87岁.既往经历至少一次纠正尿失禁手术者11例.所有病人对各种疗法无效.本组病人日间均需持续尿垫防护.按Stamey评分(0～3,0指无漏尿,3指任何活动均漏尿),2分者4例,3分者8例.详细了解病人病史、全面体检,做膀胱镜检、尿培养、药敏、录像尿流动力学测定和 GAX胶原皮试.对GAX-胶原过敏放弃治疗1例,失访1例.录像尿流动力学检查采用卧、坐、立位.卧位时,用造影剂允盈膀胱(50ml/min),直至病人有强烈尿意.经荧光屏观察漏尿和确定其类型.T型 休息状态时,膀胱颈关闭,位于耻骨联合
In recent years, the application of non-toxic injectable collagen extracted from hides and skins has been used to treat stress urinary incontinence. Currently used collagen is a kind of aldehyde crosslinked substance (GAX collagen), injected into the patient to replace Derived collagen. The authors evaluated the efficacy of transurethral injection of collagen in the treatment of stress incontinence by measuring the patient’s urine leakage and analyzing the patient’s subjective response. A total of 12 patients were confirmed by urodynamics as type I or type III stress urinary incontinence , Aged 46 to 87. Experience in at least one time to correct urinary incontinence surgery in 11 patients.All patients on a variety of therapies ineffective.This group of patients need continuous urinary pad protection during the day.According to Stamey score (0 ~ 3,0 means no Urine leakage, 3 refers to any activity were leakage of urine), 2 points in 4 cases, 3 points in 8. Detailed understanding of the patient’s medical history, a comprehensive examination, do cystoscopy, urine culture, drug sensitivity, video urodynamics and GAX Collagen skin test.Extraction of GAX-collagen allergy in 1 case, loss of follow-up in 1 case .Ultrasonic flow test using lying, sitting, standing position with the contrast agent to allow the bladder (50ml / min), until the patient There is a strong urinary intention .Fluid screen observation of leakage and determine the type .T rest Bladder neck closed, the pubic symphysis