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为探讨新型免疫抑制剂ＦＴＹ７２０对细胞毒性Ｔ细胞（ＣＴＬ）颗粒酶路径的影响及其与移植物存活的关系，我们给予同种异体心脏移植模型（ＢＮ大鼠→Ｌｅｗｉｓ大鼠）的受鼠在术前１天至术后１４天口服不同剂量的ＦＴＹ７２０（每天１ｍｇ／ｋｇ，５ｍｇ／ｋｇ和１０ｍｇ...
To investigate the effect of novel immunosuppressant FTY720 on granzyme pathway of cytotoxic T lymphocytes (CTLs) and its relationship with graft survival, we evaluated the effect of FTY720 on the cytotoxic T cell (CTL) granzyme pathway in allograft heart transplantation models (BN rats → Lewis rats) Different doses of FTY720 (1mg / kg, 5mg / kg and 10mg / day) were administered orally from day 1 to day 14