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目的:通过对经皮冠状动脉介入(PCI)术前及再次血管内超声检查前支架内再狭窄(ISR)组与非ISR组患者血清CD105水平的检测,探讨血清CD105水平与ISR的关系。方法:对140例PCI术后患者,进行冠状动脉造影及血管内超声检查并随访,造影证实非ISR组105例,共139个病变;ISR组18例,共23个病变;测量并比较两组外弹力膜横截面面积、最小管腔面积、斑块面积及内膜增生面积;术前及术后随访时均检测血清CD105水平。结果:与非ISR组外弹力膜横截面积比较,差异无统计学意义(P>0.05);ISR组有更大的内膜增生面积、斑块面积及更少的最小管腔面积。其中内膜面积、斑块面积及最小管腔面积比较,差异具有统计学意义(P<0.05)。ISR组术后CD105较术前明显升高,差异有统计学意义(P<0.05),非ISR组OCI术前后CD105水平比较,差异无统计学意义(P>0.05)。多因素Logistic回归分析显示,冠状动脉支架术后CD105水平可能是ISR的独立影响因素(OR=4.15,95%CI:3.63~5.22,P<0.05)。结论:PCI术后ISR患者CD105水平较术前升高,术后CD105水平可能有助于预测PCI术后ISR。
OBJECTIVE: To investigate the relationship between serum CD105 level and ISR by detecting the level of CD105 in patients with pre-stent restenosis (ISR) and non-ISR before and after intravascular ultrasound coronary intervention (PCI). Methods: One hundred and forty cases of post-PCI patients underwent coronary angiography and intravascular ultrasound examination and follow-up angiography confirmed non-ISR group 105 cases, a total of 139 lesions; ISR group 18 cases, a total of 23 lesions; measured and compared two groups Cross-sectional area of the outer elastic membrane, the smallest lumen area, plaque area and intimal hyperplasia area; serum CD105 levels were measured before and after follow-up. Results: Compared with non-ISR group, there was no significant difference in the cross-sectional area of the elastic membrane between the two groups (P> 0.05). ISR group had larger intimal hyperplasia area, plaque area and less lumen area. Intimal area, plaque area and the smallest lumen area, the difference was statistically significant (P <0.05). The CD105 level in the ISR group was significantly higher than that before the operation, the difference was statistically significant (P <0.05). There was no significant difference in the level of CD105 before and after OCI in non-ISR group (P> 0.05). Multivariate logistic regression analysis showed that CD105 level after coronary stenting may be an independent factor of ISR (OR = 4.15, 95% CI: 3.63-5.22, P <0.05). Conclusion: The level of CD105 in patients with ISR after PCI is higher than that before operation. The postoperative CD105 level may be helpful to predict the postoperative ISR.