肺泡巨噬细胞吞噬粉尘是尘肺发病中的主要环节,在矿物粉尘引起的疾病中,肺泡巨噬细胞被认为是最主要的研究细胞,一些研究表明,用体外培养法可观察粉尘的致纤维化性质与细胞毒性问所存在的关系,Allison(1966)的研究表明不论毒性或非毒性粉尘均会被吞噬细胞吞噬,吞噬后形成吞噬体,继而形成次级溶酶体并损害细胞而释放内容物,不同的粉尘引起的结果不同, Alveolar macrophages phagocytize dust is the main link in the pathogenesis of pneumoconiosis, alveolar macrophages are considered as the most important research cells in the diseases caused by mineral dust. Some studies show that in vitro culture can observe the fibrogenesis of dust Nature and Cytotoxicity Questions, Allison (1966) showed that toxic or non-toxic dusts are phagocytosed by phagocytes, phagocytosed to form phagosomes, which in turn form secondary lysosomes and damage cells to release the contents Different dust caused different results,