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灰黄霉素是一种早已应用具有系统作用的抗菌素药物之一,其水溶性极差,通常将药物处理成3～5μm大小的颗粒以增强溶解性.为增强其溶解性,已试验过共沉淀、冷冻干燥和固体分散等方法,结果均无明显效果.到目前为止,用环糊精衍生物(CD_s)来增强灰黄霉素的溶解性还未见报道,本文用各种方法形成的环糊精衍生物以增强其溶解性.作者试验了α-环糊精、β-环糊精、二甲基-β-环糊精和γ-环糊精,结果γ-环糊精的效果最佳,采用揉合、喷混、物理混合、共沉淀方法形成的环糊精衍生物观察灰黄霉素的溶解度,所试样品含灰黄霉素
Griseofulvin, one of the most widely used antibacterial drugs with systemic effects, is very poorly water-soluble, and is usually treated to a particle size of 3 to 5 μm for enhanced solubility. To enhance its solubility, Precipitation, freeze-drying and solid dispersion methods, the results were no significant effect so far, with cyclodextrin derivatives (CD_s) to enhance the solubility of griseofulvin has not been reported in this paper by a variety of methods Cyclodextrin derivatives to enhance their solubility The authors tested the effects of α-cyclodextrin, β-cyclodextrin, dimethyl-β-cyclodextrin and γ-cyclodextrin, as a result of γ-cyclodextrin The best, the use of blending, spray mixing, physical mixing, coprecipitation method to form the cyclodextrin derivatives observed griseofulvin solubility, the sample containing griseofulvin