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提取干酪乳酸杆菌细胞壁成分(LC-CW),研究其对人外周血LAK细胞的影响及其作用机理。结果表明,1.LC-CW可以单独或与IL-2协同,促进PBL的增殖。2.LC-CW可以增强rIL-2诱导的人外周血LAK细胞杀伤Raji细胞的作用,统计学分析有显著意义。但是单独使用LC-CW不能诱导LAK细胞杀伤活性。3.LC-CW可使PBL的CD_4~+,CD_(16)~+抗原表达增加,与IL-2协同,可增加CD_3~+、CD_4~+、CD_8~+和CD_(25)~+抗原的表达。4.LC-CW可促进PHA-P诱导的IL-2的产生。本研究结果提示LC-CW是一种重要的LAK细胞活性增强因子。
The Lactobacillus casei cell wall composition (LC-CW) was extracted to study its effect on human peripheral blood LAK cells and its mechanism of action. The results showed that, 1.LC-CW can act alone or in combination with IL-2 to promote PBL proliferation. LC-CW can enhance the effect of rIL-2-induced human peripheral blood LAK cells killing Raji cells, statistically significant. However, LC-CW alone did not induce LAK cell killing activity. LC-CW can increase the expression of CD_4 ~ + and CD16 + in PBL, and increase CD_3 ~ +, CD_4 ~ +, CD_8 ~ + and CD25 ~ + antigen expression. 4. LC-CW can promote PHA-P-induced IL-2 production. Our results suggest that LC-CW is an important LAK cell activity enhancer.