盘尾丝虫、班氏丝虫和马来丝虫一直危胁着人们的身体健康。世界卫生组织丝虫病药物开发研究的三个主要目标是:1)开发新型杀成虫药,2)开发雌性成虫绝育药,3)确认新的杀微丝蚴药,以应付因异阿凡曼菌素抗性引起的危机。 常用的两类抗蠕虫药作用于线虫神经系统配体调节的离子通道。左旋咪唑通过影响烟碱样乙酰胆碱受体(nAchR)起作用,阿凡 Onchocerciasis, Bancroftian filariasis and Malayan worm have always been a threat to people’s health. The three main goals of WHO research on filariasis drug development are: 1) developing new types of adult imazalines, 2) developing female adult sterilization, and 3) identifying new microbicidal drugs to cope with the effects of different Aman The crisis caused by mycotoxin resistance. Two commonly used anthelmintic drugs act on ion channels regulated by the nematode nervous system ligands. Levamisole acts by affecting the nicotinic acetylcholine receptor (nAchR), Avanti