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目的 :研究纯中药制剂硬肝复康对四氯化碳 (CCl4 )所致急性肝损伤和肝硬化的防治作用。方法 :将CCl4 单次或多次给予实验小白鼠 ,分别造成急性肝损伤或肝硬化 ;防治组灌胃给予硬肝复康 ,并检测各组血清中的肝脏相关酶和蛋白等指标。结果 :急性肝损伤时 ,硬肝复康 2 g/kg× 3d组血清谷丙转氨酶(ALT)和碱性磷酸酶 (ALP) ( 6153U/L± 34 91U/L和 2 0 2U /L± 2 5U/L)较对照组明显降低 ,而总蛋白(TP ,53.2 g/L± 1.9g/L)明显升高 (P <0 .0 5) ;肝硬化实验中 ,硬肝复康 2g/kg× 17d组血清ALT和ALP( 110 0± 34 2U/L和 166± 54U/L)显著低于对照组 ( 1638U/L± 336U /L和 32 8U/L± 12 8U /L) (P <0 .0 1) ,其肝、脾指数 ( 67.2± 5.2、5.0 7± 1.0 5)也明显低于对照组 ( 71.8± 4 .2、6.65± 1.81) (P <0 .0 5) ,但TP和白蛋白 (Alb) ( 68.7± 4 .8和 31.1± 2 .4 g/L)则明显高于对照组 ( 58.9g/L± 9.4 g/L和 2 9.2 g/L± 1.3g/L) (P <0 .0 5)。结论 :硬肝复康对小鼠CCl4 所致急性肝损伤和肝硬化有一定防治作用
Objective: To study the preventive and therapeutic effects of hard liver rehabilitation of pure Chinese medicine preparation on carbon tetrachloride (CCl4)-induced acute liver injury and liver cirrhosis. METHODS: CCl4 was administered to mice individually or several times to cause acute hepatic injury or cirrhosis respectively. Prevention and treatment group was given intragastric administration of hard liver rehabilitation and serum-related enzymes and proteins were detected in each group. Results: In acute liver injury, serum glutamic-pyruvic transaminase (ALT) and alkaline phosphatase (ALP) in hard liver rehabilitation 2 g/kg×3 d group (6153 U/L± 34 91 U/L and 202 U/L±2) 5U/L) was significantly lower than that in the control group, and total protein (TP, 53.2 g/L ± 1.9g/L) was significantly increased (P <0.05); liver cirrhosis test, hard liver rehabilitation 2g/kg Serum ALT and ALP levels (110 0 ± 32 2 U/L and 166 ± 54 U/L) in the 17 d group were significantly lower than those in the control group (1638 U/L ± 336 U/L and 32 8 U/L ± 12 8 U/L) (P < 0 .0 1) The liver and spleen index (67.2 ± 5.2, 5.0 7 ± 1.05) was also significantly lower than the control group (71.8 ± 4.2, 6.65 ± 1.81) (P <0.05), but the TP and Albumin (Alb) (68.7 ± 4.8 and 31.1 ± 2.4 g/L) was significantly higher than the control group (58.9 g/L ± 9.4 g/L and 29.2 g/L ± 1.3 g/L) ( P <0. 0 5). Conclusion :Hangganfukang may prevent and treat acute liver injury and liver cirrhosis caused by CCl4 in mice