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重症肌无力(MG)是以神经肌肉传导改变为特征的一种典型的获得性自身免疫性疾病.85%以上的MG患者血清中有不同水平的抗乙酰胆碱受体(AchR)的自身抗体,但其滴度与疾病的严重程度无严格的相关性.最近证明MG患者的胸腺及外周血中的T细胞对重组白细胞介素2(rIL-2)的反应性增强,可不通过预先刺激而被rIL=2激活,提示MG患者可能有IL-2R调控和/或表达的异常可溶性白细胞介素2受体(sIL-2R).的血清水平是细胞激活的早期标志,在细胞sIL-2R生长期间可能还具有免疫调节功能.通过测定sIL-2R在胸腺切除术前和术后的血清水平,研究MG患者免疫系统的活化状态及估计在随访中sIL-2R是否可作为疾病严重程度的标志.
Myasthenia Gravis (MG) is a classic acquired autoimmune disease characterized by altered neuromuscular transmission, with more than 85% of MG patients having different levels of anti-AchR autoantibodies in their sera but The titers are not strictly related to the severity of the disease.Recent evidence has shown that T cells in the thymus and peripheral blood of patients with MG have an increased reactivity to recombinant interleukin 2 (rIL-2) without rIL = 2 activation, suggesting that serum levels of abnormal soluble interleukin 2 receptor (sIL-2R), which may be regulated and / or expressed by IL-2R in MG patients, are early markers of cellular activation that may be involved in the growth of sIL-2R cells Also has immunomodulatory function.Study the activation status of the immune system in MG patients by measuring the serum levels of sIL-2R before and after thymectomy and assessing whether sIL-2R can be used as a marker of disease severity at follow-up.