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大多数大环内酯类药物是目前应用最广泛的口服抗菌药。近年来其抗感染外作用已成为国外研究热点。这些作用的发现不仅拓宽了其应用范围,也为某些难治疾病提供了新的治疗方法。本文就近年大环内酯类药物的抗感染外作用作一综述。1 促胃肠蠕动作用 Shiba等经实验证实,红霉素对胃肠平滑肌在离体、空腹和饱餐三种状态下均具有明显的促动力作用,且与剂量呈正相关。有量小于50μg/(kg·h)时无作用,200～400μg/(kg·h)时则引起胃肠强烈收缩。Janssens(1995年)用红霉素250mg三餐后口服治疗糖尿病胃轻瘫;用5～10 mg/(kg·d)的剂量治疗新生儿胃内食物雍滞症,均获得显著疗效。三餐前口
Most macrolides are currently the most widely used oral antibacterials. In recent years, its anti-infective effect has become a hot research topic in foreign countries. The discovery of these effects not only broadens the scope of its application, but also provides new treatments for some refractory diseases. This review summarizes the anti-infective effects of macrolides in recent years. 1 promote gastrointestinal motility Shiba and other experiments confirmed that erythromycin on gastrointestinal smooth muscle in vitro, fasting and full meal all three states have a significant role in promoting the force, and with a dose-related. In the amount of less than 50μg / (kg · h) no effect, 200 ~ 400μg / (kg · h) caused when the gastrointestinal strong contraction. Janssens (1995) treated with erythromycin 250mg three meals after oral treatment of diabetic gastroparesis; with 5 ~ 10 mg / (kg · d) dose of neovascularization in the stomach of newborns, have achieved significant results. Three meals before the mouth