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[目的]观察舒眠胶囊联合匹维溴铵治疗老年肠易激综合征(irritable bowel syndrome,IBS)的临床效果。[方法]76例老年IBS患者采用随机化方法分为观察组和对照组各38例。观察组在服用匹维溴铵片的基础上联合服用舒眠胶囊,对照组仅服用匹维溴铵片,疗程均为6周。观察2组治疗前后各项IBS症状评分、IBS生活质量评价量表(IBS-quality of life,IBS-QOL)、抑郁自评量表(self-rating depression scale,SDS)和焦虑自评量表(self-rating anxiety scale,SAS)的变化。[结果]观察组腹痛、腹胀、大便次数、大便性状的改善率显著高于对照组(P<0.05);观察组IBS-QOL烦躁不安、行为冲突、身体意象、健康忧虑4个维度的改善率显著高于对照组(P<0.05);观察组SDS和SAS的改善率均显著高于对照组(P<0.05)。[结论]在口服匹维溴铵治疗老年IBS的基础上,舒眠胶囊可以进一步提高疗效。
[Objective] To observe the clinical effect of Shuming Capsule combined with piroxicam on the treatment of irritable bowel syndrome (IBS) in the elderly. [Method] A total of 76 elderly patients with IBS were divided into observation group and control group by randomized method. The observation group taking pinaverium bromide tablets on the basis of combination of Shumeng Capsules, the control group took only pivaloprotassium bromide tablets, the course of treatment were 6 weeks. The IBS symptom score, IBS-quality of life (IBS-QOL), self-rating depression scale (SDS) and anxiety self-rating scale self-rating anxiety scale, SAS). [Results] The improvement rates of abdominal pain, abdominal distension, stool frequency and stool of the observation group were significantly higher than those of the control group (P <0.05). The improvement rate of IBS-QOL irritability, behavioral conflict, body image and health anxiety in the observation group (P <0.05). The improvement rates of SDS and SAS in the observation group were significantly higher than those in the control group (P <0.05). [Conclusion] On the basis of oral pivalivoxil treatment of IBS in the elderly, Shumeng Capsule can further improve the curative effect.