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目的 了解成人与儿童急性B淋巴细胞性白血病 (B -ALL)中CD34和伴系抗原表达的情况及两者是否有所不同。方法 应用流式细胞术测定了 10 8例初治成人B -ALL及 5 3例初治儿童B -ALL的免疫表型 ,并对结果进行比较分析。结果 在成人与儿童中 ,CD34+的B -ALL伴髓系抗原 (CD13或CD33)表达 (My+)的比例明显高于CD34-的B -ALL ;而两者之间无论是CD34阳性的比例还是伴系抗原表达的比例 ,均无显著差异。结论 无论是儿童还是成人My+B -ALL ,均主要来源于造血干祖细胞的恶性转化。初治儿童与成人B -ALL比较 ,它们的免疫学表型特征相似
Objective To investigate the expression of CD34 and its associated antigen in adult and childhood acute B-lymphoblastic leukemia (B-ALL) and whether the two are different. Methods The immunophenotypes of 108 untreated adult B -ALLs and 53 untreated children with B-ALL were determined by flow cytometry. The results were compared and analyzed. Results In adults and children, the proportion of CD34 + B-ALL with myeloid antigen (CD13 or CD33) expression (My +) was significantly higher than that of CD34- B-ALL. However, the proportion of both CD34 + positive and CD34 + The proportion of antigens expressed no significant difference. Conclusion My + B-ALL, both children and adults, mainly came from the malignant transformation of hematopoietic stem and progenitor cells. Compared with adult B-ALL, the children of the newly diagnosed children had similar immunophenotypic characteristics