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虽然甲状腺毒症时下丘脑-垂体-睾丸轴有轻微的改变,但有关雄激素增多或减少的临床证据很少。为此,本文研究甲状腺机能亢进症(甲亢)时血清游离和结合睾酮水平与睾酮结合蛋白之间的关系。病人和方法甲亢病人20例,男9例,未孕女性11例。所有病人均经甲状腺功能试验、甲状腺~(99m)Tc扫描、抗微粒体抗体值及临床检查确诊为Graves病。病人每隔6～8周抽血复查1次,当游离T_3(FT_3)和游离T_4(FT_4)持续正常至少3个月即作为甲状腺功能正常而复查。甲亢及甲状腺功能正常时分别测有关激素水平。结果甲亢时与甲状腺功能正常时相比:总睾酮男分别为37.3±4.0nmol/L比15.3±1.5nmol/L(P<0.01);女分别为2.4±0.3
Although there is a slight change in the hypothalamus-pituitary-testicular axis during thyrotoxicosis, there is little clinical evidence for an increase or decrease in androgens. To this end, this article studies the relationship between serum free and conjugated testosterone levels and testosterone-binding protein in hyperthyroidism (hyperthyroidism). Patients and methods Hyperthyroidism patients 20 cases, 9 males, 11 females not pregnant. All patients were diagnosed as Graves’ disease by thyroid function test, thyroid ~ (99m) Tc scan, anti-microsomal antibody value and clinical examination. The patient was inspected every 6 to 8 weeks for a repeat examination of blood, and the free T_3 (FT_3) and free T_4 (FT_4) remained normal for at least 3 months and were reviewed as normal thyroid function. Hyperthyroidism and thyroid function were normal when the hormone levels were measured. Results Hyperthyroidism compared with normal thyroid function: total testosterone were 37.3 ± 4.0nmol / L than 15.3 ± 1.5nmol / L (P <0.01); women were 2.4 ± 0.3