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为了研究胃癌患者术后免疫功能的变化并选择合适的时机进行化疗,作者对48例胃癌患者术后不同时期和化疗前后外周血NK细胞活性和T细胞亚群进行了检测。结果显示,肿瘤切除后第二周和第三周患者免疫功能均有明显改善,但二者无明显差别(P>0.05)。说明术后免疫功能恢复到一定程度后稳定在一定水平。因此从免疫状态看,术后一周左右化疗是合适的。另外化疗前后免疫指标变化揭示,化疗对患者免疫功能确有损害作用。
In order to study the changes in postoperative immunologic function of gastric cancer patients and choose the right time for chemotherapy, the authors detected the NK cell activity and T cell subpopulations in 48 patients with gastric cancer at different periods after surgery and before and after chemotherapy. The results showed that the immune function of patients at the second and third weeks after tumor resection was significantly improved, but there was no significant difference between the two (P>0.05). It shows that after the recovery of immune function to a certain extent, it is stable at a certain level. Therefore, from the immune status, about one week after chemotherapy is appropriate. In addition, changes in immune parameters before and after chemotherapy revealed that chemotherapy does impair the immune function of patients.