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纤联素(Fibronectin,纤维连结蛋白)是一种多功能的高分子量(44万)糖蛋白。它分为组织型与血浆型两种,各由两条相同的多肽链经二硫键联成。血浆纤联素(以下称PFN)主要起调理素作用,能促进巨噬细胞与中性粒细胞清除纤维蛋白凝集物,胶原组织碎片,免疫复合物,肿瘤细胞,细菌等颗粒状物质,参与机体对感染、肿瘤的防御机制。它的含量影响机体的非特异性免疫功能的高低。并有实验表明纤联素参与防止心、肺、脑等重要脏器的微栓塞及器官损伤,在
Fibronectin (fibronectin) is a versatile, high molecular weight (440,000) glycoprotein. It is divided into tissue type and plasma type, and each is composed of two identical polypeptide chains joined by disulfide bonds. Plasma fibronectin (hereinafter referred to as PFN) mainly acts as an opsonizing factor and can promote macrophage and neutrophil clearance of fibrin agglutinates, collagen tissue fragments, immune complexes, tumor cells, bacteria and other particulate substances, and participate in the body. The defense mechanism against infections and tumors. Its content affects the body’s non-specific immune function. Experiments have shown that fibronectin is involved in the prevention of microembolism and organ damage in important organs such as heart, lung, and brain.