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雌三醇—雌1、3、5(10)三烯—3β、16α,17β-三醇是从孕妇尿中分离出来的第二种雌激素。非孕妇通过肝脏对原始雌激素-17β-雌二醇和雌酮进行改造合成雌三醇。妊娠时胎儿-胎盘系统产生雌三醇。妊娠后半期该激素80%由胎源性硫酸脱氢表雄酮(硫酸ДЭА)合成,仅10%由姆体硫酸ДЭА合成。硫酸ДЭА通过两条途径转化为雌三醇。主要途径包括:胎儿肾上腺皮质分泌的硫酸ДЭА在胎肝内16α-羟化,形成的硫酸16α-羟ДЭА在胎盘内脱硫,又在3β-羟类固醇脱氢酶-异构酶系统作用下转化为
Estriol-estrogen 1,3,5 (10) triene-3β, 16α, 17β-triol is the second estrogen isolated from the urine of pregnant women. Non-pregnant women through the liver of the original estrogen-17β-estradiol and estrone transformation of the synthesis of estriol. The fetus-placental system produces estriol during pregnancy. 80% of the hormone in the second trimester of pregnancy by the fetal source of dehydroepiandrosterone sulfate (ДЭА sulfuric acid) synthesis, only 10% by the body of sulfuric acid ДЭА synthesis. Sulphate ДЭА is converted to estriol by two routes. The main ways include: fetal adrenal secretion of sulfuric acid ДЭ А in fetal liver 16α-hydroxylation of the formation of 16α-hydroxy ДЭА sulfate in the placenta desulfurization, but also in the 3β-hydroxysteroid dehydrogenase-isomerase system into