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本文用小剂量人白细胞干扰素治疗慢性乙型肝炎(30例)及病毒携带者(10例)共40例,干扰素32.000u,肌肉注射,每周3次,治疗观察6个月。其 HBsAg 滴度几何平均值从治疗前1:100.4,3个月下降为1:25.1,6个月为1:17.2,P<0.001,HBsAg 转阴21/40例,占52.5%。6个月后,HBeAg 13/20例转阴,占65%,有抗一 HBe 出现11例;HBcAg2/4例转阴,88.9%的病例 DNAP 为阴性,73.1%的病例 HBV-DNA 为阴性伴 DNAP 阴性。30例肝炎病人的病毒指标转阴优于病毒携带者。对照组20例用聚肌胞治疗6个月,病毒指标无明显改善。从以上五项病毒指标在治疗后下降和转阴,表明小剂量干扰素对乙肝病毒复制有抑制作用。
In this paper, a small dose of human leukocyte interferon treatment of chronic hepatitis B (30 cases) and virus carriers (10 cases) a total of 40 cases, interferon 32.000u, intramuscular injection, three times a week, the treatment observed for 6 months. The geometric mean HBsAg titer decreased from 1: 100.4 before treatment to 1: 25.1 in 3 months, 1: 17.2 in 6 months, 21/40 with 52.00% in HBsAg negative patients, P <0.001. Six months later, 13 of HBeAg was negative, accounting for 65%, 11 of the patients had anti-HBe, negative of HBcAg2 / 4, negative of DNAP of 88.9%, negative of HBV DNA of 73.1% DNAP negative. The viral index of 30 hepatitis patients was better than that of virus carriers. Control group of 20 patients treated with poly-muscle cells for 6 months, no significant improvement in viral markers. From the above five indicators of viral decline in treatment and negative, indicating that low-dose interferon on hepatitis B virus replication inhibition.