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据J Pediatr(1995,126:94)文载 美国的一项研究资料显示,用合成的肺表面活化剂抢救患有呼吸窘迫综合征的低体重新生儿,能提高其存活率。 这项分析是以一项多中心、有安慰剂对照的临床试验结果为基础,该试验的研究对象为419名出生体重700g至1350g的新生儿,表面活化剂试验组的新生儿在生后2～24小时接受人工合成的肺表面活化剂5ml/kg,如果患儿仍需机械辅助肺通气,则12小时后再接受同一剂量的肺表面活化剂。
According to a study by J Pediatr (1995, 126: 94) in the United States, the use of synthetic lung surfactant to rescue low birth weight neonates with respiratory distress syndrome improves their survival. The analysis was based on the results of a multicenter, placebo-controlled clinical trial of 419 newborns with a birth weight of 700g to 1350g and neonates with a surfactant test group of 2 Synthetic lung surfactant 5 ml / kg for ~ 24 hours and the same dose of pulmonary surfactant 12 hours later if the patient still requires mechanical a-pulmonary ventilation.