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目的 :研究 C-erb B-2在 LN(-)乳腺癌中的表达对判断预后的意义。方法 :1 0 a内随访 LN(-)乳腺癌病人 49例 ,用链霉素生物蛋白 -过氧化物酶免疫组化染色法 (S-P法 )测定石蜡标本中 C-erb B-2的表达 ,结合临床和病理资料分析其作用。结果 :49例 LN(-)乳腺癌中 ,2 3例 C-erb B-2阳性 ,阳性率 46.93 % ,C-erb B-2阳性表达与无瘤生存率、5 a生存率、总生存率有关 (P <0 .0 5 ) ,与局部复发、远处转移有关 (P <0 .0 5 )。结论 :C-erb B-2阳性的乳腺癌病人预后差 ,易转移、易复发 ,总生存率、5 a生存率、无瘤生存率均低 ,因此 LN(-)乳腺癌病人测定 C-erb B-2对临床制定治疗方案和判定预后有重要意义。
Objective: To investigate the significance of C-erb B-2 expression in LN (-) breast cancer. Methods: Forty-nine patients with LN (-) breast cancer were followed up within 10 days. The expression of C-erb B-2 in paraffin specimens was determined by streptavidin-peroxidase immunohistochemistry (SP method) Combined with clinical and pathological data analysis of its role. Results: Among 49 cases of LN (-) breast cancer, 23 cases were positive for C-erb B-2, the positive rate was 46.93%. The positive expression rate of C-erb B-2 was related to the tumor-free survival rate, 5-year survival rate, (P <0.05), which was associated with local recurrence and distant metastasis (P <0.05). CONCLUSIONS: C-erb B-2 positive breast cancer patients have poor prognosis, easy metastasis and relapse, overall survival, 5-year survival and tumor-free survival rates. Therefore, C-erb B-2 for the clinical development of treatment programs and determine the prognosis of great significance.