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已有报道从黄病毒科鉴定出几种新的肝炎病毒,分别被命名为GBV-C肝炎病毒和庚型肝炎病毒(HGV)。Genbank数据库有其全序列,很明显它们是同一病毒的不同株。HGV被认为与散发性肝炎、暴发性肝炎和输血后肝炎有关,但以前还没有HGV血源感染的分子依据。作者发现2例HGV感染者,序列分析表明感染方式与受血有关。一个男性患者(R1)56岁,诊断为重症再生障碍性贫血;另一个女性患者(R2)42岁,诊断为丙型肝炎、肝硬化晚期。逆转录—多聚酶链反应(RT-PCR)检测发现R1的第1份血清样品和随后的几份血清样品为HGV RNA阳性。R2肝移植前的3份血清样
Several new hepatitis viruses have been identified from the Flaviviridae family and have been named GBV-C and GGV, respectively. The Genbank database has its full sequence, and it is clear that they are different strains of the same virus. HGV is thought to be associated with sporadic hepatitis, fulminant hepatitis and post-transfusion hepatitis, but no molecular basis for HGV infection has been previously available. The authors found 2 cases of HGV infection, sequence analysis showed that infection and blood-related. One male patient (R1) was 56 years old and was diagnosed with severe aplastic anemia; the other female patient (R2) was 42 years old and was diagnosed with hepatitis C and advanced cirrhosis. Reverse transcription-polymerase chain reaction (RT-PCR) tests revealed that the first serum sample of R1 and the subsequent serum samples were positive for HGV RNA. R2 before liver transplantation 3 serum samples