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目的观察宫颈电环切除术联合重组人干扰素治疗宫颈上皮内瘤变(CIN)Ⅰ级合并人乳头瘤病毒(HPV)感染的治疗效果。方法将41例CINⅠ合并HPV感染患者随机分为2组,观察组21例给予宫颈电环切除术(LEEP)联合重组人干扰素治疗,对照组20例给予单纯LEEP治疗,观察2组总有效率和HPV持续感染情况。结果观察组愈合率为85.7%显著高于对照组的60.0%,差异有统计学意义(P<0.05);2组总有效率比较差异无统计学意义(P>0.05);观察组HPV持续感染率低于对照组,差异有统计学意义(P<0.05)。结论宫颈电环切除术联合重组人干扰素治疗CINⅠ合并HPV感染疗效显著,无明显不良反应,可显著降低HPV持续感染率,值得临床推广应用。
Objective To observe the therapeutic effect of cervical electrocorticoid excision combined with recombinant human interferon in the treatment of cervical intraepithelial neoplasia (CIN) and human papillomavirus (HPV) infection. Methods 41 cases of CINⅠwith HPV infection were randomly divided into two groups. The observation group received 21 cases of LEEP combined with recombinant interferon (IFN) and the control group of 20 cases treated with LEEP. The total effective rate And persistent HPV infection. Results The healing rate in observation group was significantly higher than that in control group (85.7% vs 60.0%, P <0.05). There was no significant difference in total effective rate between two groups (P> 0.05) The rate was lower than the control group, the difference was statistically significant (P <0.05). Conclusion Cervical electrocautery resection combined with recombinant human interferon in the treatment of CIN Ⅰ with HPV infection has a significant effect, no obvious adverse reactions, can significantly reduce the persistent HPV infection rate, worthy of clinical application.