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目的:研究盐酸普拉克索联合美多巴对老年帕金森病的临床疗效及对运动功能的影响。方法:选择2014年3月~2015年8月在我院进行诊治的老年帕金森病患者210例,随机分为观察组和对照组,对照组给予美多巴,观察组给予盐酸普拉克索联合美多巴,比较两组的临床疗效,治疗前后运动功能、生活质量的变化情况和不良反应的发生情况。结果:观察组的治疗有效率为85.71%,明显高于对照组的65.71%(P<0.05);治疗12周后,观察组UPDRS评分与治疗前和对照组相比均明显降低(P<0.05);治疗12周后,观察组生理、心理、独立性、社会关系和环境等方面的评分与治疗前和对照组相比均明显升高(P<0.05);两组间恶心、呕吐、开关现象、精神症状等不良反应发生率相比无明显差异(P>0.05)。结论:盐酸普拉克索联合美多巴对老年帕金森病疗效显著,能明显改善运动功能,且用药安全,值得推广应用。
Objective: To study the clinical efficacy of pramipexole hydrochloride combined with meridose in elderly Parkinson’s disease and its effect on motor function. Methods: A total of 210 senile patients with Parkinson’s disease who were diagnosed and treated in our hospital from March 2014 to August 2015 were randomly divided into the observation group and the control group, the control group received metoparol, the observation group received pramipexole hydrochloride combined Medopa, comparing the two groups of clinical efficacy, exercise function before and after treatment, changes in the quality of life and the incidence of adverse reactions. Results: The effective rate of observation group was 85.71%, which was significantly higher than that of control group (65.71%, P <0.05). After 12 weeks of treatment, UPDRS score of observation group was significantly lower than that before treatment and control group (P <0.05 ); After 12 weeks of treatment, the score of the observation group in physiology, psychology, independence, social relations and environment were significantly higher than those before treatment and in the control group (P <0.05); Nausea and vomiting, switch Phenomenon, psychiatric symptoms and other adverse reactions compared with no significant difference (P> 0.05). Conclusion: The combination of pramipexole hydrochloride and metopah has significant effects on senile Parkinson’s disease, which can significantly improve motor function and safety of medication. It is worth to be popularized and applied.