论文部分内容阅读
目的了解东莞市东城区自然人群的麻疹血清抗体水平,为针对性开展麻疹防治提供科学依据。方法按照多阶段分层抽样方法从东莞市东城区抽出1个城市中心村和1个农村,每个村落各抽取276人,共552人,采取血清;用ELISA法检测人群血清中麻疹IgG抗体水平。结果 552人中抗体阳性548人,阳性率99.3%,几何平均滴度(GMT)1:1618.2。以5～14岁儿童抗体阳性率最高,为100%,GMT则从5岁开始下降至中低等水平,在15～59岁组又上升到高水平。男性与女性麻疹抗体阳性率分别为99.28%、99.26%,GMT分别为1:1569.87和1:1672.39,男女之间麻疹抗体阳性率及不同滴度水平麻疹抗体阳性率差异均无统计学意义(P﹥0.05)。城市中心区与农村地区的麻疹抗体水平差异存在统计学意义(χ2=12.502,P﹤0.05),中心村人群麻疹抗体滴度水平较高。结论东莞市东城区自然人群麻疹抗体水平较高,有群体免疫屏障作用。但需要关注大龄儿童的麻疹疫苗复种问题以及加强农村地区人口的麻疹监测和流动人口的麻疹疫苗接种工作,尽量减少易感人群的积累,为维持人群有较高的麻疹抗体水平,防止麻疹疫情的出现。
Objective To understand the serum levels of measles in natural population in Dongcheng District of Dongguan City and provide a scientific basis for the targeted prevention and treatment of measles. Methods According to the multi-stage stratified sampling method, 1 urban center village and 1 rural area were extracted from Dongcheng District, Dongguan City. 276 were sampled from each village, 552 in total. Serum was detected by ELISA. The level of measles IgG in serum . Results Among the 552 patients, 548 were positive for antibody, the positive rate was 99.3%, and the geometric mean titer (GMT) was 1: 1618.2. The highest positive rate was 100% in children aged 5-14 years. The GMT decreased from the age of 5 to the middle and low levels, and then rose to a high level in the 15-59 years old group. The positive rates of measles antibody between male and female were 99.28% and 99.26% respectively, the GMT was 1: 1569.87 and 1: 1672.39, respectively. There was no significant difference in the positive rate of measles antibody between male and female and the positive rate of measles antibody at different titer (P > 0.05). Measles antibody levels in urban centers and rural areas were statistically significant (χ2 = 12.502, P <0.05), and measles antibody titers in central village were higher. Conclusion The level of measles antibody in natural population in Dongcheng District of Dongguan City is relatively high, with immune barrier function. However, it is necessary to pay attention to the problem of multiple measles vaccine for older children and to strengthen the measles surveillance of migrant population in rural areas and to measles vaccination of floating population so as to minimize the accumulation of susceptible people, to maintain a high measles antibody level for the population and to prevent the outbreak of measles appear.