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目的探讨复合型鼠类不育剂CQ-1对鸡的安全性。方法试验设不育剂饵料4个浓度为0、10、15、20mg/kg,对鸡连续无选择饲喂10d,给药结束继续观察30d后解剖所有个体,记录鸡的一般体征、取食量、体重、产蛋率、内脏器官等指标,并与对照组比较,评价复合型鼠类不育剂CQ-1对非靶动物的安全性。结果不育剂处理下鸡的一般体征无明显异常,对照组的取食量最高为(0.44±0.12)g/kg,3个不育剂处理组取食量均显著低于对照组,鸡平均食入纯药量最高为20mg/kg的处理达(4.20±1.44)μg/kg。3个处理组鸡的体重有暂时性下降,而对照组鸡的体重持续增长。3个处理组鸡的产蛋率均有下降,15mg/kg处理组下降幅度最多,达到49.3%,第41～50天,3个不育剂处理组产蛋率回升均可恢复正常。解剖检查脏器,3个不育剂处理组均无明显异常,内脏系数和对照组相比差异无统计学意义。结论复合型鼠类不育剂CQ-1对鸡毒性较小,最高浓度20mg/kg连续无选择饲喂10d不会导致鸡死亡,虽然不育剂会使鸡的体重和产蛋率下降,但均可恢复。
Objective To investigate the safety of compound mouse steroid CQ-1 on chickens. Methods Four infertility baits were tested at 0, 10, 15, and 20 mg / kg. The chickens were continuously fed without any treatment for 10 days. All animals were dissected after the end of the treatment for 30 days. The general signs of the chickens, , Body weight, egg laying rate, internal organs and other indicators, and compared with the control group, to evaluate the safety of compound type IV steroid CQ-1 on non-target animals. Results There was no obvious abnormality in the general signs of the chickens treated with the infertile agents. The highest feed intake of the control group was (0.44 ± 0.12) g / kg, and the feed intake of the three treatment groups was significantly lower than that of the control group Intake of pure drugs up to 20mg / kg of the treatment up to (4.20 ± 1.44) μg / kg. The body weight of three treatment groups had a temporary decrease, while the control group of chicken body weight continued to grow. The egg production rate of three treatment groups decreased, while that of 15mg / kg treatment group decreased by 49.3%. From the 41st to the 50th day, the egg production rate of three treatment groups returned to normal. Anatomical examination of organs, three infertility treatment group were no significant abnormalities, visceral coefficient compared with the control group, no significant difference. Conclusions The compound type of mouse infertility CQ-1 is less toxic to chickens. The highest concentration of 20mg / kg without continuous feeding for 10 days will not cause death of chickens. Although the infertility agent will reduce the body weight and laying rate of chickens, Can be restored.