患者男,54岁。2年前出现双下肢乏力伴四肢末端麻木,逐渐加重,现主因双足行走如踩棉花感、不能站立入院。既往痛风病史10余年。体检:四肢及关节僵硬,可触及痛风结节,双下肢肌萎缩伴Babinski征阳性,双膝腱及跟腱反射活跃,四肢针刺觉减退。实验室检查:尿酸520μmol/L(正常值140~42 Male patient, 54 years old. Two years ago, both lower extremity weakness accompanied by extremities end numbness, and gradually increased, now mainly due to bipedal walking, such as cotton, can not stand admitted. Past gout history more than 10 years. Physical examination: limbs and joints stiff, gouty nodules can be reached, both lower extremity muscle atrophy with Babinski sign positive, double tendon and Achilles tendon reflex, limb acupuncture diminished. Laboratory tests: uric acid 520μmol / L (normal 140 ~ 42