文章简介自噬体的形成调控机制是细胞自噬研究的重要内容。LC3在自噬体膜的延伸和成熟中发挥着关键的作用。自噬体是在细胞质内形成的,但长期以来人们发现LC3大量定位在细胞核中,其在核内的作用及其意义一直未得到解决。本研究发现,在营养充足的情况下,LC3以乙酰化形式存在于细胞质和细胞核;在诱导自噬发生时,位于细胞核内的LC3在第49位和51位赖氨酸被激活的脱乙 Article Introduction The regulatory mechanism of autophagosomes is an important part of autophagy research. LC3 plays a key role in the extension and maturation of autophagosomes. Autophagosomes are formed in the cytoplasm, but LC3 has long been found in the nucleus, its role in the nucleus and its significance has not been solved. The present study found that LC3 is present in the cytoplasm and nucleus in an acetylated form when nutrition is adequate and that LC3 located in the nucleus at the 49th and 51th lysine-activated sites is deacetylated upon induction of autophagy